Global gene expression profiling of oral cavity cancers suggests molecular heterogeneity within anatomic subsites.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is a frequent neoplasm, which is usually aggressive and has unpredictable biological behavior and unfavorable prognosis. The comprehension of the molecular basis of this variability should lead to the development of targeted therapies as well as to improvements in specificity and sensitivity of diagnosis.

Results

Samples of primary OSCCs and their corresponding surgical margins were obtained from male patients during surgery and their gene expression profiles were screened using whole-genome microarray technology. Hierarchical clustering and Principal Components Analysis were used for data visualization and One-way Analysis of Variance was used to identify differentially expressed genes. Samples clustered mostly according to dis

SUBMITTER: Severino P 

PROVIDER: S-EPMC2632665 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature