At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.

ABSTRACT:

Background

Genomic imprinting is an exception to Mendelian genetics in that imprinted genes are expressed monoallelically, dependent on parental origin. In mammals, imprinted genes are critical in numerous developmental and physiological processes. Aberrant imprinted gene expression is implicated in several diseases including Prader-Willi/Angelman syndromes and cancer.

Methodology/principal findings

To identify novel imprinted genes, transcription profiling was performed on two uniparentally derived cell lines, androgenetic and parthenogenetic primary mouse embryonic fibroblasts. A maternally expressed transcript termed Imprinted RNA near Meg3/Gtl2 (Irm) was identified and its expression studied by Northern blotting and whole mounts in situ hybridization. The imprinted regio

SUBMITTER: Hagan JP 

PROVIDER: S-EPMC2632752 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature