Different phases of long-term memory require distinct temporal patterns of PKA activity after single-trial classical conditioning.

ABSTRACT: The cAMP-dependent protein kinase (PKA) is known to play a critical role in both transcription-independent short-term or intermediate-term memory and transcription-dependent long-term memory (LTM). Although distinct phases of LTM already have been demonstrated in some systems, it is not known whether these phases require distinct temporal patterns of learning-induced PKA activation. This question was addressed in a robust form of associative LTM that emerges within a matter of hours after single-trial food-reward classical conditioning in the pond snail Lymnaea stagnalis. After establishing the molecular and functional identity of the PKA catalytic subunit in the Lymnaea nervous system, we used a combination of PKA activity measurement and inhibition techniques to investigate its role in L

SUBMITTER: Michel M 

PROVIDER: S-EPMC2632788 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature