Motif discovery in promoters of genes co-localized and co-expressed during myeloid cells differentiation.

ABSTRACT: Genes co-expressed may be under similar promoter-based and/or position-based regulation. Although data on expression, position and function of human genes are available, their true integration still represents a challenge for computational biology, hampering the identification of regulatory mechanisms. We carried out an integrative analysis of genomic position, functional annotation and promoters of genes expressed in myeloid cells. Promoter analysis was conducted by a novel multi-step method for discovering putative regulatory elements, i.e. over-represented motifs, in a selected set of promoters, as compared with a background model. The combination of transcriptional, structural and functional data allowed the identification of sets of promoters pertaining to groups of genes co-expressed

SUBMITTER: Coppe A 

PROVIDER: S-EPMC2632922 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature