Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity.

ABSTRACT:

Rationale

Obstructive sleep apnea is associated with insulin resistance and liver injury. It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity.

Objectives

To examine whether sleep apnea and nocturnal hypoxemia predict the severity of insulin resistance, systemic inflammation, and steatohepatitis in severely obese individuals presenting for bariatric surgery.

Methods

We performed sleep studies and measured fasting blood glucose, serum insulin, C-reactive protein, and liver enzymes in 90 consecutive severely obese individuals, 75 women and 15 men, without concomitant diabetes mellitus or preexistent diagnosis of sleep apnea or liver disease. Liver biopsies (n = 20) were obtained during bariatric surgery.

Measurements and

SUBMITTER: Polotsky VY 

PROVIDER: S-EPMC2633055 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature