Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.

ABSTRACT:

Rationale

Extracellular superoxide dismutase (EC-SOD) is a potent antioxidant that plays an important role in controlling oxidant-mediated stress and inflammation. High levels of EC-SOD are found in the lung. Acute lung injury (ALI) frequently occurs in patients with infection, and levels of EC-SOD have been shown to modulate severity of lung injury in transgenic animal models of endotoxemia-induced ALI. An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease.

Objectives

To determine genetic variation in the promoter and EC-SOD gene and to examine whether EC-SOD haplotype blocks are associated with clinical outcomes.

Methods

We sequenced the E

SUBMITTER: Arcaroli JJ 

PROVIDER: S-EPMC2633057 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature