Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors.

ABSTRACT:

Background

Ewing sarcoma family of tumors (ESFT), characterized by t(11;22)(q24;q12), is one of the most common tumors of bone in children and young adults. In addition to EWS/FLI1 gene fusion, copy number changes are known to be significant for the underlying neoplastic development of ESFT and for patient outcome. Our genome-wide high-resolution analysis aspired to pinpoint genomic regions of highest interest and possible target genes in these areas.

Methods

Array comparative genomic hybridization (CGH) and expression arrays were used to screen for copy number alterations and expression changes in ESFT patient samples. A total of 31 ESFT samples were analyzed by aCGH and in 16 patients DNA and RNA level data, created by expression arrays, was integrated. Time of the follow-

SUBMITTER: Savola S 

PROVIDER: S-EPMC2633345 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature