Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2.

ABSTRACT:

Background

Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. However, it is not known whether genetic polymorphisms of CYP2J2 are associated with increased cardiovascular risks.

Methods and results

All 9 exons of the CYP2J2 gene and its proximal promoter were sequenced in 132 patients to identify potential variants. Functional consequence of a single nucleotide polymorphism (SNP) in the promoter of CYP2J2 was further evaluated by use of transcription factor-binding and reporter assays. A total of 17 polymorphisms were identified. One of the most relevant polymorphisms in terms of freque

SUBMITTER: Spiecker M 

PROVIDER: S-EPMC2633457 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature