Age and gender related differences in human parotid gland gene expression.

ABSTRACT:

Objective

The present study evaluated differences in gene expression associated with age and gender in the human parotid gland.

Design

Parotid gland tissue was analysed using the Affymetrix GeneChip HGU133plus2.0 array.

Results

Differential gene expression, defined as a statistically significant difference with a 1.5-fold or greater change, was detected in 787 gene probe sets; 467 (approximately 59%) showed higher expression in females. Several genes associated with saliva secretion were differentially expressed in male and female parotid glands including vesicle-associated membrane protein 3 VAMP3, synaptosomal-associated protein SNAP23, RAS oncogene family member RAB1A and the syntaxin binding protein STXBP1. Evaluation of gene expression in the youngest and the old

SUBMITTER: Srivastava A 

PROVIDER: S-EPMC2633719 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature