Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice.

ABSTRACT: The absence of specific immune response is a hallmark of prion diseases. However, in vitro and in vivo experiments have provided evidence that an anti-PrP humoral response could have beneficial effects. Prophylactic passive immunization performed at the time of infection delayed or prevented disease. Nonetheless, the potential therapeutic effect of PrP antibodies administered shortly before the clinical signs has never been tested in vivo. Moreover, a recent study showed the potential toxicity of PrP antibodies administered intracerebrally. We aimed at evaluating the effect of a prolonged intracerebral anti-PrP antibody administration at the time of neuroinvasion in BSE infected Tg20 mice. Unexpectedly, despite a good penetration of the antibodies in the brain parenchyma, the treatment was

SUBMITTER: Lefebvre-Roque M 

PROVIDER: S-EPMC2634593 | biostudies-literature | 2007 Jul-Sep

REPOSITORIES: biostudies-literature