Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning.

ABSTRACT:

Background

The hypothesis of the present study was that molecular mechanisms differ markedly when mediating ischemic preconditioning induced by repetitive episodes of ischemia versus classic first- or second-window preconditioning.

Methods and results

To test this, chronically instrumented conscious pigs were subjected to either repetitive coronary stenosis (RCS) or a traditional protocol of second-window ischemic preconditioning (SWIPC). Lethal ischemia, induced by 60 minutes of coronary artery occlusion followed by reperfusion, resulted in an infarct size/area at risk of 6+/-3% after RCS and 16+/-3% after SWIPC (both groups P<0.05, less than shams 42+/-4%). Two molecular signatures of SWIPC, the increased expression of the inducible isoform of nitric oxide synthase and the

SUBMITTER: Shen YT 

PROVIDER: S-EPMC2634862 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature