Identification of potential pathway mediation targets in Toll-like receptor signaling.

ABSTRACT: Recent advances in reconstruction and analytical methods for signaling networks have spurred the development of large-scale models that incorporate fully functional and biologically relevant features. An extended reconstruction of the human Toll-like receptor signaling network is presented herein. This reconstruction contains an extensive complement of kinases, phosphatases, and other associated proteins that mediate the signaling cascade along with a delineation of their associated chemical reactions. A computational framework based on the methods of large-scale convex analysis was developed and applied to this network to characterize input-output relationships. The input-output relationships enabled significant modularization of the network into ten pathways. The analysis identified pote

SUBMITTER: Li F 

PROVIDER: S-EPMC2634968 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature