Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression.

ABSTRACT:

Background

Ascorbic acid (AA), or Vitamin C, is most well known as a nutritional supplement with antioxidant properties. Recently, we demonstrated that high concentrations of AA act on PMP22 gene expression and partially correct the Charcot-Marie-Tooth disease phenotype in a mouse model. This is due to the capacity of AA, but not other antioxidants, to down-modulate cAMP intracellular concentration by a competitive inhibition of the adenylate cyclase enzymatic activity. Because of the critical role of cAMP in intracellular signalling, we decided to explore the possibility that ascorbic acid could modulate the expression of other genes.

Methods and findings

Using human pangenomic microarrays, we found that AA inhibited the expression of two categories of genes necessary for c

SUBMITTER: Belin S 

PROVIDER: S-EPMC2634969 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature