Kinetic model for lamellipodal actin-integrin 'clutch' dynamics.

ABSTRACT: In migrating cells, with especial prominence in lamellipodial protrusions at the cell front, highly dynamic connections are formed between the actin cytoskeleton and the extracellular matrix through linkages of integrin adhesion receptors to actin filaments via complexes of cytosolic "connector" proteins. Myosin-mediated contractile forces strongly influence the dynamic behavior of these adhesion complexes, apparently in two counter-acting ways: negatively as the cell-generated forces enhance complex dissociation, and at the same time positively as force-induced signaling can lead to strengthening of the linkage complexes. The net balance arising from this dynamic interplay is challenging to ascertain a priori, rendering experimental studies difficult to interpret and molecular manipulatio

SUBMITTER: Macdonald A 

PROVIDER: S-EPMC2634992 | biostudies-literature | 2008 Apr-May

REPOSITORIES: biostudies-literature