Detailed transcriptome atlas of the pancreatic beta cell.

ABSTRACT:

Background

Gene expression patterns provide a detailed view of cellular functions. Comparison of profiles in disease vs normal conditions provides insights into the processes underlying disease progression. However, availability and integration of public gene expression datasets remains a major challenge. The aim of the present study was to explore the transcriptome of pancreatic islets and, based on this information, to prepare a comprehensive and open access inventory of insulin-producing beta cell gene expression, the Beta Cell Gene Atlas (BCGA).

Methods

We performed Massively Parallel Signature Sequencing (MPSS) analysis of human pancreatic islet samples and microarray analyses of purified rat beta cells, alpha cells and INS-1 cells, and compared the information with ava

SUBMITTER: Kutlu B 

PROVIDER: S-EPMC2635377 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature