A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.

ABSTRACT: Pulmonary tissue damage resulting from influenza virus infection is caused by both the cytolytic activity of the virus and the host immune response. Immune-mediated injury results from T cell-mediated destruction of virus-infected cells and by release of cytokines and chemokines that attract polymorphonuclear leukocytes (PML) and macrophages to the infected site. The cytokines/chemokines potentiate dendritic cell (DC) activation and T cell expansion, which further enhances local damage. Here we report that immune modulation by local administration to the respiratory tract of sphingosine analog AAL-R significantly dampens the release of cytokines and chemokines while maintaining protective neutralizing antibody and cytotoxic T cell responses. As a result there was a marked reduction of infi

SUBMITTER: Marsolais D 

PROVIDER: S-EPMC2635800 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature