Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43.

ABSTRACT: Gap junction proteins, connexins, provide intercellular channels that allow ions and small signaling molecules to be transmitted to adjacent coupled cells. Besides this function, it is becoming apparent that connexins also exert channel-independent effects, which are likely mediated by processes involving protein-protein interactions. Although a number of connexin interacting proteins have been identified, only little is known about the functional consequences of such interactions. We have previously shown that deletion of the astrocytic gap junction protein, connexin43 (Cx43) causes a right-ward shift in the dose-response curve to P2Y1R agonists and decreased P2Y1R expression levels. To evaluate whether these changes were due to reduced gap junctional communication or to protein-protein i

SUBMITTER: Scemes E 

PROVIDER: S-EPMC2636557 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature