Evolution of prokaryotic SPFH proteins.

ABSTRACT:

Background

The SPFH protein superfamily is a diverse family of proteins whose eukaryotic members are involved in the scaffolding of detergent-resistant microdomains. Recently the origin of the SPFH proteins has been questioned. Instead, convergent evolution has been proposed. However, an independent, convergent evolution of three large prokaryotic and three eukaryotic families is highly unlikely, especially when other mechanisms such as lateral gene transfer which could also explain their distribution pattern have not yet been considered.To gain better insight into this very diverse protein family, we have analyzed the genomes of 497 microorganisms and investigated the pattern of occurrence as well as the genomic vicinity of the prokaryotic SPFH members.

Results

According to

SUBMITTER: Hinderhofer M 

PROVIDER: S-EPMC2636767 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature