ALC: automated reduction of rule-based models.

ABSTRACT:

Background

Combinatorial complexity is a challenging problem for the modeling of cellular signal transduction since the association of a few proteins can give rise to an enormous amount of feasible protein complexes. The layer-based approach is an approximative, but accurate method for the mathematical modeling of signaling systems with inherent combinatorial complexity. The number of variables in the simulation equations is highly reduced and the resulting dynamic models show a pronounced modularity. Layer-based modeling allows for the modeling of systems not accessible previously.

Results

ALC (Automated Layer Construction) is a computer program that highly simplifies the building of reduced modular models, according to the layer-based approach. The model is defined using a

SUBMITTER: Koschorreck M 

PROVIDER: S-EPMC2636783 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature