Patterns of exon-intron architecture variation of genes in eukaryotic genomes.

ABSTRACT:

Background

The origin and importance of exon-intron architecture comprises one of the remaining mysteries of gene evolution. Several studies have investigated the variations of intron length, GC content, ordinal position in a gene and divergence. However, there is little study about the structural variation of exons and introns.

Results

We investigated the length, GC content, ordinal position and divergence in both exons and introns of 13 eukaryotic genomes, representing plant and animal. Our analyses revealed that three basic patterns of exon-intron variation were present in nearly all analyzed genomes (P < 0.001 in most cases): an ordinal reduction of length and divergence in both exon and intron, a co-variation between exon and its flanking introns in their length, GC con

SUBMITTER: Zhu L 

PROVIDER: S-EPMC2636830 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature