LRRCE: a leucine-rich repeat cysteine capping motif unique to the chordate lineage.

ABSTRACT:

Background

The small leucine-rich repeat proteins and proteoglycans (SLRPs) form an important family of regulatory molecules that participate in many essential functions. They typically control the correct assembly of collagen fibrils, regulate mineral deposition in bone, and modulate the activity of potent cellular growth factors through many signalling cascades. SLRPs belong to the group of extracellular leucine-rich repeat proteins that are flanked at both ends by disulphide-bonded caps that protect the hydrophobic core of the terminal repeats. A capping motif specific to SLRPs has been recently described in the crystal structures of the core proteins of decorin and biglycan. This motif, designated as LRRCE, differs in both sequence and structure from other, more widespread leuc

SUBMITTER: Park H 

PROVIDER: S-EPMC2637281 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature