Regulatory networks define phenotypic classes of human stem cell lines.

ABSTRACT: Stem cells are defined as self-renewing cell populations that can differentiate into multiple distinct cell types. However, hundreds of different human cell lines from embryonic, fetal and adult sources have been called stem cells, even though they range from pluripotent cells-typified by embryonic stem cells, which are capable of virtually unlimited proliferation and differentiation-to adult stem cell lines, which can generate a far more limited repertoire of differentiated cell types. The rapid increase in reports of new sources of stem cells and their anticipated value to regenerative medicine has highlighted the need for a general, reproducible method for classification of these cells. We report here the creation and analysis of a database of global gene expression profiles (which we c

SUBMITTER: Muller FJ 

PROVIDER: S-EPMC2637443 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature