The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation.

ABSTRACT:

Purpose of review

This review will focus on the coming proliferation of amyloid-beta imaging tracers and give an opinion on how the Alzheimer's disease field can develop a systematic means of evaluating which tracers are useful and how the useful tracers compare to each other.

Recent findings

Several new tracers have been reported to be useful for human amyloid-beta imaging. The most recent of these are labeled with fluorine-18. Compared with the 20 min half-life of carbon-11 used in the most widely used tracer, Pittsburgh Compound-B, the 110 min half-life of fluorine-18 allows for wider utilization in research and clinical settings.

Summary

It is likely that more than one fluorine-18-labeled tracer will come into common use. The use of preclinical and clinical 'bridg

SUBMITTER: Klunk WE 

PROVIDER: S-EPMC2637561 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature