Large-scale prediction of long disordered regions in proteins using random forests.

ABSTRACT:

Background

Many proteins contain disordered regions that lack fixed three-dimensional (3D) structure under physiological conditions but have important biological functions. Prediction of disordered regions in protein sequences is important for understanding protein function and in high-throughput determination of protein structures. Machine learning techniques, including neural networks and support vector machines have been widely used in such predictions. Predictors designed for long disordered regions are usually less successful in predicting short disordered regions. Combining prediction of short and long disordered regions will dramatically increase the complexity of the prediction algorithm and make the predictor unsuitable for large-scale applications. Efficient batch predict

SUBMITTER: Han P 

PROVIDER: S-EPMC2637845 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature