Comparative transcriptomic analysis of Porphyromonas gingivalis biofilm and planktonic cells.

ABSTRACT:

Background

Porphyromonas gingivalis in subgingival dental plaque, as part of a mature biofilm, has been strongly implicated in the onset and progression of chronic periodontitis. In this study using DNA microarray we compared the global gene expression of a P. gingivalis biofilm with that of its planktonic counterpart grown in the same continuous culture.

Results

Approximately 18% (377 genes, at 1.5 fold or more, P-value < 0.01) of the P. gingivalis genome was differentially expressed when the bacterium was grown as a biofilm. Genes that were down-regulated in biofilm cells, relative to planktonic cells, included those involved in cell envelope biogenesis, DNA replication, energy production and biosynthesis of cofactors, prosthetic groups and carriers. A number of genes enco

SUBMITTER: Lo AW 

PROVIDER: S-EPMC2637884 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature