Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata.

ABSTRACT: In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel chromosomes. Apparently, this yeast can generate a n

SUBMITTER: Polakova S 

PROVIDER: S-EPMC2637908 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature