Cross-study projections of genomic biomarkers: an evaluation in cancer genomics.

ABSTRACT: Human disease studies using DNA microarrays in both clinical/observational and experimental/controlled studies are having increasing impact on our understanding of the complexity of human diseases. A fundamental concept is the use of gene expression as a "common currency" that links the results of in vitro controlled experiments to in vivo observational human studies. Many studies--in cancer and other diseases--have shown promise in using in vitro cell manipulations to improve understanding of in vivo biology, but experiments often simply fail to reflect the enormous phenotypic variation seen in human diseases. We address this with a framework and methods to dissect, enhance and extend the in vivo utility of in vitro derived gene expression signatures. From an experimentally defined gene e

SUBMITTER: Lucas JE 

PROVIDER: S-EPMC2638006 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature