Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis.

ABSTRACT:

Background

Although insulin analogues are commonly prescribed for the management of diabetes mellitus, there is uncertainty regarding their optimal use. We conducted meta-analyses to compare the outcomes of insulin analogues with conventional insulins in the treatment of type 1, type 2 and gestational diabetes.

Methods

We updated 2 earlier systematic reviews of the efficacy and safety of rapid-and long-acting insulin analogues. We searched electronic databases, conference proceedings and "grey literature" up to April 2007 to identify randomized controlled trials that compared insulin analogues with conventional insulins. Study populations of interest were people with type 1 and type 2 diabetes (adult and pediatric) and women with gestational diabetes.

Results

We inclu

SUBMITTER: Singh SR 

PROVIDER: S-EPMC2638025 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature