Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments.

ABSTRACT: The synthesis of both the AEFG macrolactam and the CDEFG bis-indole/tyrosine units found in the marine natural product diazonamide A is presented. Key to the success of the synthesis is the highly stereoselective direct C-arylation of an oxindole by an aryllead(IV) reagent derived from tyrosine.

SUBMITTER: Lin J 

PROVIDER: S-EPMC2638117 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature