The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags.

ABSTRACT: Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight against cancer, we have deposited some two million expressed sequence tags (ESTs) from human tumors and their corresponding normal tissues in the public databases. The data currently define approximately 23,500 genes, of which only approximately 1,250 are still represented only by ESTs. Examination of the EST coverage of known cancer-related (CR) genes reveals that <1% do not have corresponding ESTs, indicating that the representation of genes associated with commonly studied tumors is high. The careful recording of the origin of all ESTs we hav

SUBMITTER: Brentani H 

PROVIDER: S-EPMC263829 | biostudies-literature | 2003 Nov

REPOSITORIES: biostudies-literature