KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors.

ABSTRACT:

Motivation

We noted that the sumoylation site in C/EBP homologues is conserved beyond the canonical consensus sequence for sumoylation. Therefore, we investigated whether this pattern might define a more general protein motif.

Results

We undertook a survey of the human proteome using a regular expression based on the C/EBP motif. This revealed significant enrichment of the motif using different Gene Ontology terms (e.g. 'transcription') that pertain to the nucleus. When considering requirements for the motif to be functional (evolutionary conservation, structural accessibility of the motif and proper cell localization of the protein), more than 130 human proteins were retrieved from the UniProt/Swiss-Prot database. These candidates were particularly enriched in transcription

SUBMITTER: Diella F 

PROVIDER: S-EPMC2638927 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature