Identification of structurally conserved residues of proteins in absence of structural homologs using neural network ensemble.

ABSTRACT:

Motivation

So far various bioinformatics and machine learning techniques applied for identification of sequence and functionally conserved residues in proteins. Although few computational methods are available for the prediction of structurally conserved residues from protein structure, almost all methods require homologous structural information and structure-based alignments, which still prove to be a bottleneck in protein structure comparison studies. In this work, we developed a neural network approach for identification of structurally important residues from a single protein structure without using homologous structural information and structural alignment.

Results

A neural network ensemble (NNE) method that utilizes negative correlation learning (NCL) approach was dev

SUBMITTER: Pugalenthi G 

PROVIDER: S-EPMC2638999 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature