LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data.

ABSTRACT:

Motivation

The elucidation of biological pathways enriched with differentially expressed genes has become an integral part of the analysis and interpretation of microarray data. Several statistical methods are commonly used in this context, but the question of the optimal approach has still not been resolved.

Results

We present a logistic regression-based method (LRpath) for identifying predefined sets of biologically related genes enriched with (or depleted of) differentially expressed transcripts in microarray experiments. We functionally relate the odds of gene set membership with the significance of differential expression, and calculate adjusted P-values as a measure of statistical significance. The new approach is compared with Fisher's exact test and other relevant me

SUBMITTER: Sartor MA 

PROVIDER: S-EPMC2639007 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature