Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

ABSTRACT:

Background

Endometriosis has a strong genetic component, and numerous genetic studies have been reported.

Methods

We have systematically reviewed these studies and included 114 in our final selection.

Results

We found no consistent evidence linking endometriosis with specific polymorphisms in genes encoding inflammatory mediators, proteins involved in sex steroid metabolism, vascular function and tissue remodelling. Although a number of polymorphisms have been associated with endometriosis in selected populations, the associations have not been independently confirmed, either because only single studies were carried out on these markers/genes or because other studies reported no association. The most solid evidence linking specific polymorphisms to endometriosis came

SUBMITTER: Tempfer CB 

PROVIDER: S-EPMC2639061 | biostudies-literature | 2009 Jan-Feb

REPOSITORIES: biostudies-literature