Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women.

ABSTRACT:

Objectives

To compare the effectiveness of cranberry extract with low-dose trimethoprim in the prevention of recurrent urinary tract infections (UTIs) in older women.

Patients and methods

One hundred and thirty-seven women with two or more antibiotic-treated UTIs in the previous 12 months were randomized to receive either 500 mg of cranberry extract or 100 mg of trimethoprim for 6 months.

Results

Thirty-nine of 137 participants (28%) had an antibiotic-treated UTI (25 in the cranberry group and 14 in the trimethoprim group); difference in proportions relative risk 1.616 (95% CI: 0.93, 2.79) P = 0.084. The time to first recurrence of UTI was not significantly different between the groups (P = 0.100). The median time to recurrence of UTI was 84.5 days for the cranberry g

SUBMITTER: McMurdo ME 

PROVIDER: S-EPMC2639265 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature