Systems-level modeling of cellular glycosylation reaction networks: O-linked glycan formation on natural selectin ligands.

ABSTRACT:

Motivation

The emerging field of Glycomics requires the development of systems-based modeling strategies to relate glycosyltransferase gene expression and enzyme activity with carbohydrate structure and function.

Results

We describe the application of object oriented programming concepts to define glycans, enzymes, reactions, pathways and compartments for modeling cellular glycosylation reaction networks. These class definitions are combined with current biochemical knowledge to define potential reaction networks that participate in the formation of the sialyl Lewis-X (sLe(X)) epitope on O-glycans linked to a leukocyte cell-surface glycoprotein, P-selectin Glycoprotein Ligand-1 (PSGL-1). Subset modeling, hierarchical clustering, principal component analysis and adjoint sensi

SUBMITTER: Liu G 

PROVIDER: S-EPMC2639277 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature