An open access database of genome-wide association results.

ABSTRACT:

Background

The number of genome-wide association studies (GWAS) is growing rapidly leading to the discovery and replication of many new disease loci. Combining results from multiple GWAS datasets may potentially strengthen previous conclusions and suggest new disease loci, pathways or pleiotropic genes. However, no database or centralized resource currently exists that contains anywhere near the full scope of GWAS results.

Methods

We collected available results from 118 GWAS articles into a database of 56,411 significant SNP-phenotype associations and accompanying information, making this database freely available here. In doing so, we met and describe here a number of challenges to creating an open access database of GWAS results. Through preliminary analyses and characteri

SUBMITTER: Johnson AD 

PROVIDER: S-EPMC2639349 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature