Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi.

ABSTRACT:

Background

In eukaryotic cells, directional transport between different compartments of the endomembrane system is mediated by vesicles that bud from a donor organelle and then fuse with an acceptor organelle. A family of integral membrane proteins, termed soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins, constitute the key machineries of these different membrane fusion events. Over the past 30 years, the yeast Saccharomyces cerevisiae has served as a powerful model organism for studying the organization of the secretory and endocytic pathways, and a few years ago, its entire set of SNAREs was compiled.

Results

Here, we make use of the increasing amount of genomic data to investigate the history of the SNARE family during fungi evolution. Moreov

SUBMITTER: Kienle N 

PROVIDER: S-EPMC2639358 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature