Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains.

ABSTRACT:

Background

Extraintestinal pathogenic Escherichia coli (ExPEC) strains represent a huge public health burden. Knowledge of their clonal diversity and of the association of clones with genomic content and clinical features is a prerequisite to recognize strains with a high invasive potential. In order to provide an unbiased view of the diversity of E. coli strains responsible for bacteremia, we studied 161 consecutive isolates from patients with positive blood culture obtained during one year in two French university hospitals. We collected precise clinical information, multilocus sequence typing (MLST) data and virulence gene content for all isolates. A subset representative of the clonal diversity was subjected to comparative genomic hybridization (CGH) using 2,324 amplicons from

SUBMITTER: Jaureguy F 

PROVIDER: S-EPMC2639426 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature