Pep-3D-Search: a method for B-cell epitope prediction based on mimotope analysis.

ABSTRACT:

Background

The prediction of conformational B-cell epitopes is one of the most important goals in immunoinformatics. The solution to this problem, even if approximate, would help in designing experiments to precisely map the residues of interaction between an antigen and an antibody. Consequently, this area of research has received considerable attention from immunologists, structural biologists and computational biologists. Phage-displayed random peptide libraries are powerful tools used to obtain mimotopes that are selected by binding to a given monoclonal antibody (mAb) in a similar way to the native epitope. These mimotopes can be considered as functional epitope mimics. Mimotope analysis based methods can predict not only linear but also conformational epitopes and this has be

SUBMITTER: Huang YX 

PROVIDER: S-EPMC2639436 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature