Variation in nicotine consumption in inbred mice is not linked to orosensory ability.

ABSTRACT: Genetic studies of nicotine addiction in mice have utilized the oral self-administration model. However, it is unclear if strain differences in nicotine consumption are influenced by variation in bitter taste sensitivity. We measured both nicotine consumption and nicotine brief-access licking behavior in several commonly used inbred strains of mice that were previously shown to differ in nicotine consumption. A/J (A), C57BL/6J (B6), and DBA/2J (D2) mice were given a 2-bottle choice test with a single concentration of nicotine (75 microg/ml; nicotine vs. water). Mice of these strains were also tested with a range of nicotine concentrations (5-400 microg/ml) using a brief-access test, which measures orosensory response and minimizes postingestive effects. Although B6 mice consumed more 75-mi

SUBMITTER: Glatt AR 

PROVIDER: S-EPMC2639451 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature