Intragenic tandem repeat variation between Legionella pneumophila strains.

ABSTRACT:

Background

Bacterial genomes harbour a large number of tandem repeats, yet the possible phenotypic effects of those found within the coding region of genes are only beginning to be examined. Evidence exists from other organisms that these repeats can be involved in the evolution of new genes, gene regulation, adaptation, resistance to environmental stresses, and avoidance of the immune system.

Results

In this study, we have investigated the presence and variability in copy number of intragenic tandemly repeated sequences in the genome of Legionella pneumophila, the etiological agent of a severe pneumonia known as Legionnaires' disease. Within the genome of the Philadelphia strain, we have identified 26 intragenic tandem repeat sequences using conservative selection criteria.

SUBMITTER: Coil DA 

PROVIDER: S-EPMC2639597 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature