Ranking of binding and nonbinding peptides to MHC class I molecules using inverse folding approach: implications for vaccine design.

ABSTRACT: T cell recognition of the peptide-MHC complex initiates a cascade of immunological events necessary for immune responses. Accurate T-cell epitope prediction is an important part of the vaccine designing. Development of predictive algorithms based on sequence profile requires a very large number of experimental binding peptide data to major histocompatibility complex (MHC) molecules. Here we used inverse folding approach to study the peptide specificity of MHC Class-I molecule with the aim of obtaining a better differentiation between binding and nonbinding sequence. Overlapping peptides, spanning the entire protein sequence, are threaded through the backbone coordinates of a known peptide fold in the MHC groove, and their interaction energies are evaluated using statistical pairwise contac

SUBMITTER: Singh SP 

PROVIDER: S-EPMC2639678 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature