Macrophage responses to silica nanoparticles are highly conserved across particle sizes.

ABSTRACT: Concerns about the potential adverse health effects of engineered nanoparticles stems in part from the possibility that some materials display unique chemical and physical properties at nanoscales which could exacerbate their biological activity. However, studies that have assessed the effect of particle size across a comprehensive set of biological responses have not been reported. Using a macrophage cell model, we demonstrate that the ability of unopsonized amorphous silica particles to stimulate inflammatory protein secretion and induce macrophage cytotoxicity scales closely with the total administered particle surface area across a wide range of particle diameters (7-500 nm). Whole genome microarray analysis of the early gene expression changes induced by 10- and 500-nm particles showe

SUBMITTER: Waters KM 

PROVIDER: S-EPMC2639757 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature