Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease.

ABSTRACT:

Background

MicroRNAs (miRNAs) play key roles in mammalian gene expression and several cellular processes, including differentiation, development, apoptosis and cancer pathomechanisms. Recently the biological importance of primary cilia has been recognized in a number of human genetic diseases. Numerous disorders are related to cilia dysfunction, including polycystic kidney disease (PKD). Although involvement of certain genes and transcriptional networks in PKD development has been shown, not much is known how they are regulated molecularly.

Results

Given the emerging role of miRNAs in gene expression, we explored the possibilities of miRNA-based regulations in PKD. Here, we analyzed the simultaneous expression changes of miRNAs and mRNAs by microarrays. 935 genes, classified

SUBMITTER: Pandey P 

PROVIDER: S-EPMC2640396 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature