Regulation of the ankyrin-B-based targeting pathway following myocardial infarction.

ABSTRACT:

Aims

Ion channel reorganization is a critical step in the pro-arrhythmogenic remodelling process that occurs in heart disease. Ankyrin-B (AnkB) is required for targeting and stabilizing ion channels, exchangers, and pumps. Despite a wealth of knowledge implicating the importance of AnkB in human cardiovascular physiology, nothing is known regarding the role of AnkB in common forms of acquired human disease.

Methods and results

We present the first report of AnkB regulation following myocardial infarction (MI). AnkB protein levels were reduced in the infarct border zone 5 days following coronary artery occlusion in the canine. We also observed a dramatic increase in AnkB mRNA levels 5 days post-occlusion. Surprisingly, the expression of the upstream AnkB cytoskeletal componen

SUBMITTER: Hund TJ 

PROVIDER: S-EPMC2642599 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature