PASTAA: identifying transcription factors associated with sets of co-regulated genes.

ABSTRACT:

Motivation

A major challenge in regulatory genomics is the identification of associations between functional categories of genes (e.g. tissues, metabolic pathways) and their regulating transcription factors (TFs). While, for a limited number of categories, the regulating TFs are already known, still for many functional categories the responsible factors remain to be elucidated.

Results

We put forward a novel method (PASTAA) for detecting transcriptions factors associated with functional categories, which utilizes the prediction of binding affinities of a TF to promoters. This binding strength information is compared to the likelihood of membership of the corresponding genes in the functional category under study. Coherence between the two ranked datasets is seen as an indica

SUBMITTER: Roider HG 

PROVIDER: S-EPMC2642637 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature