Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies.

ABSTRACT: Human neurons express the innate immune response receptor, Toll-like receptor 3 (TLR3). TLR3 levels are increased in pathological conditions such as brain virus infection. Here, we further investigated the production, cellular localisation, and function of neuronal TLR3 during neuronotropic rabies virus (RABV) infection in human neuronal cells. Following RABV infection, TLR3 is not only present in endosomes, as observed in the absence of infection, but also in detergent-resistant perinuclear inclusion bodies. As well as TLR3, these inclusion bodies contain the viral genome and viral proteins (N and P, but not G). The size and composition of inclusion bodies and the absence of a surrounding membrane, as shown by electron microscopy, suggest they correspond to the previously described Negri

SUBMITTER: Menager P 

PROVIDER: S-EPMC2642728 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature