Bioinformatic flowchart and database to investigate the origins and diversity of clan AA peptidases.

ABSTRACT:

Background

Clan AA of aspartic peptidases relates the family of pepsin monomers evolutionarily with all dimeric peptidases encoded by eukaryotic LTR retroelements. Recent findings describing various pools of single-domain nonviral host peptidases, in prokaryotes and eukaryotes, indicate that the diversity of clan AA is larger than previously thought. The ensuing approach to investigate this enzyme group is by studying its phylogeny. However, clan AA is a difficult case to study due to the low similarity and different rates of evolution. This work is an ongoing attempt to investigate the different clan AA families to understand the cause of their diversity.

Results

In this paper, we describe in-progress database and bioinformatic flowchart designed to characterize the clan AA

SUBMITTER: Llorens C 

PROVIDER: S-EPMC2642776 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature