Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages.

ABSTRACT:

Background

Skeletal muscle mass can be markedly reduced through a process called atrophy, as a consequence of many diseases or critical physiological and environmental situations. Atrophy is characterised by loss of contractile proteins and reduction of fiber volume. Although in the last decade the molecular aspects underlying muscle atrophy have received increased attention, the fine mechanisms controlling muscle degeneration are still incomplete. In this study we applied meta-analysis on gene expression signatures pertaining to different types of muscle atrophy for the identification of novel key regulatory signals implicated in these degenerative processes.

Results

We found a general down-regulation of genes involved in energy production and carbohydrate metabolism and up

SUBMITTER: Calura E 

PROVIDER: S-EPMC2642825 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature